“化学反应与机制”系列学术报告
报告题目：Catalysts for the Asymmetric Hydrogenation of Imines
报告人：Robert H. Morris 教授
多伦多大学化学系
时间：2022年9月29日 9:30-11:00
地点：腾讯会议 959-649-263
报告摘要：The chiral center of many pharmaceuticals and agrochemicals is installed by the addition of dihydrogen across the C=N bond of a prochiral imine catalyzed by a ruthenium or iridium complex containing an enantiopure chelating diphosphine ligand. For example, the largest asymmetric hydrogenation industrial process uses a complex of iridium containing a diphosphine with a ferrocene backbone to make an effective herbicide containing an (S)-stereocenter next to an amino group with a very bulky aryl group. We have recently proposed, based on Density Functional Calculations, the first plausible mechanism for this process. The enantiodetermining step is the transfer of a hydride from an iridium trihydride complex to an iminium carbon under mild conditions in the presence of an acid under a pressure of dihydrogen. I will discuss the development, using a combination of experiment and theory, of some of the first catalysts based on complexes of iron and manganese for the asymmetric hydrogenation of polar C=O and C=N bonds with the goal of replacing the precious metals ruthenium and iridium.
报告人简介：Professor Robert H. Morris was past Chair of the Department of the Chemistry at the University of Toronto in Canada. He was born in Ottawa, Canada, in 1952. He received his PhD from the University of British Columbia in 1978. After postdoctoral work at the Nitrogen Fixation Laboratory, University of Sussex and the Pennsylvania State University he joined the faculty of the University of Toronto in 1980. He was appointed full Professor there in 1989 and Chair in 2010. His research interests include inorganic, organic and catalytic chemistry with applications in the fine chemical industry. In all Morris has published over 200 articles and 8 book chapters and holds three patents. His work has been recognized within Canada with the Rutherford Medal in Chemistry from the Royal Society of Canada in 1991, the CSC Alcan Lecture Award, 1995 and the Award for Pure or Applied Inorganic Chemistry, 1998. He is a fellow of the Chemical Institute of Canada and a Fellow of the Royal Society of Canada. He received the Canadian Green Chemistry and Engineering Network Award in 2017. With the RSC he served as Director of the Division of Mathematical and Physical Sciences.